Bases Neuronales del Comportamiento
Dr. Mariano Belluscio
JEFE DE GRUPO / Group LEADER
Investigador Adjunto CONICET
Jefe de Trabajos Prácticos – UBA
Contact: mabelluscio@fbmc.fcen.uba.ar
Gran parte de nuestras acciones están orientadas a obtener recompensas o evitar daños. Para ello, necesitamos tener memoria de nuestro entorno, evaluar los costos y beneficios de nuestras acciones y ser capaces de medir el tiempo para ejecutarlas en el momento preciso. Así, nuestro cerebro nos permite actuar de la manera correcta en el momento indicado. En el laboratorio buscamos comprender los mecanismos neuronales fundamentales que subyacen a estas diversas funciones cognitivas. Para ello, registramos la actividad neuronal mientras los roedores realizan diversos paradigmas comportamentales.
Most of our actions are oriented towards obtaining rewards or avoiding harm. To achieve this, we need to remember our environment, evaluate the costs and benefits of our actions, and be able to measure time to execute them at the precise moment. Thus, our brain allows us to act in the right way at the right time. In the laboratory, we seek to understand the fundamental neural mechanisms underlying these diverse cognitive functions. To this end, we record neural activity while rodents perform various behavioral paradigms.
Gran parte de nuestras acciones son para obtener recompensas o a evadir daños. Para eso, necesitamos tener memoria de nuestro entorno, ser capaces de medir el tiempo y evaluar costos y beneficios de nuestras acciones para actuar de la manera correcta en el momento indicado. Nuestro objetivo es comprender los mecanismos neuronales fundamentales para la realización de estas diferentes funciones cognitivas. Para ello desarrollamos distintos paradigmas comportamentales en roedores y registramos su actividad neuronal de manera simultanea.
Accordion Content
Publicaciones seleccionadas:
- Retrieval of contextual memory can be predicted by CA3 remapping and is differentially influenced by NMDAR activity in rat hippocampus subregions. Magdalena M*, Silva A*, Morici JF, Coletti MA, Belluscio MA*, Bekinschtein P*.(*contributed equally to this work) Plos Biology, 2024 Jul 1,
- Dorsal striatum coding for the timely execution of action sequences. Martinez MC, Zold CL, Coletti MA, Murer MG*, Belluscio MA*. (*contributed equally to this work) Elife, 2022 Nov 25, (11),
- Dynamical Models in Neuroscience From a Closed-Loop Control Perspective. Martinez S, Garcia-Violini D, Belluscio M, Piriz J, Sanchez-Pena R. IEEE Rev Biomed Eng, 2023, (16), 706-721
- Serotonin Type 2a Receptor in the Prefrontal Cortex Controls Perirhinal Cortex Excitability During Object Recognition Memory Recall. Morici JF, Cicuttin G, Silva A, Gallo FT, Miranda M, Belluscio M, Zold C, Bekinschtein P, Weisstaub NV. Neuroscience, 2022 Aug 10, (497), 196-205
- Multielectrode Recordings From Identified Neurons Involved in Visually Elicited Escape Behavior. Cámera A, Belluscio MA, Tomsic D. Front Behav Neurosci, 2020, (14), 592309
- Volume-Conducted Origin of the Field Potential at the Lateral Habenula. Bertone-Cueto NI, Makarova J, Mosqueira A, García-Violini D, Sánchez-Peña R, Herreras O, Belluscio M*, Piriz J*. (*contributed equally to this work) Front Syst Neurosci, 2019, (13), 78
- Inducible ablation of dopamine D2 receptors in adult mice impairs locomotion, motor skill learning and leads to severe parkinsonism. Bello EP, Casas-Cordero R, Galiñanes GL, Casey E, Belluscio MA, Rodríguez V, Noaín D, Murer MG, Rubinstein M. Mol Psychiatry, 2017 Apr, 4 (22), 595-604
- Spike sorting for large, dense electrode arrays. Rossant C, Kadir SN, Goodman DFM, Schulman J, Hunter MLD, Saleem AB, Grosmark A, Belluscio M, Denfield GH, Ecker AS, Tolias AS, Solomon S, Buzsaki G, Carandini M, Harris KD. Nat Neurosci, 2016 Apr, 4 (19), 634-641
- Closed-loop control of epilepsy by transcranial electrical stimulation. Berényi A, Belluscio M, Mao D, Buzsáki G. Science, 2012 Aug 10, 6095 (337), 735-7
- Large-scale recording of neurons by movable silicon probes in behaving rodents. Vandecasteele M, M S, Royer S, Belluscio M, Berényi A, Diba K, Fujisawa S, Grosmark A, Mao D, Mizuseki K, Patel J, Stark E, Sullivan D, Watson B, Buzsáki G. J Vis Exp, 2012 Mar 4, 61 (), e3568
- Cross-frequency phase-phase coupling between θ and γ oscillations in the hippocampus. Belluscio MA, Mizuseki K, Schmidt R, Kempter R, Buzsáki G. J Neurosci, 2012 Jan 11, 2 (32), 423-35
Subsidios:
Premios
Integrantes del grupo / Lab Members
Ing Marcos Coletti
Doctorado (FFyB UBA)
Dr Santiago Merlo
Becario Postdoctoral
Paloma Ramirez
Becaria Doctoral (FCEyN UBA)
Franco Gomez Rodriguez
Becario Doctoral (FCEyN UBA)
Miembros Anteriores
Dra Daniela Piña-Novo
Dra Azul Silva
Lic Camila Polotto
Lic Isidro Gauto
Lic Nicolás Deschle