Posts in category: Publicaciones – Pecci

-Alvarez LD, Dansey MV, Ogara MF, Peña C, Houtman R, Veleiro AS, Pecci A,  Burton G. Cholestenoic Acid Analogues as Inverse Agonists of the Liver X Receptors. J. Steroid Biochem & Mol. Biol (en prensa).

–Rocha-Viegas L, Silbermins M; Ogara MF, Pellegrini JM, Nuñez SY, García VE, Vicent GP and Pecci A. Glucocorticoids uncover a critical role for ASH2L on BCL-X expression regulation in leukemia cells. Biochimica et Biophysica Acta – Gene Regulatory Mechanisms. Biochim Biophys Acta Gene Regul Mech. 2019 Dec 20:194475. doi: 10.1016/j.bbagrm.2019.194475.

–Alves, NC, Pecci, A, Alvarez, L. Structural insights into the ligand binding domain of the glucocorticoid receptor: a molecular dynamics study. Journal of Chemical Information and Modeling. 2019 Nov 14. doi: 10.1021/acs.jcim.9b00776.

–Ogara MF, Rodríguez-Seguí SA, Marini M, Nacht AS, Stortz M, Levi V, Presman DM, Vicent GP, Pecci A. The glucocorticoid receptor interferes with progesterone receptor-dependent genomic regulation in breast cancer cells. Nucleic Acids Res. 2019 Oct 10. pii: gkz857. doi: 10.1093/nar/gkz857.

–Alvarez LD, Pecci A. Mapping the neurosteroid bindingsitesonglycinereceptors. J SteroidBiochem Mol Biol. 2019 Jun 6;192:105388. doi: 10.1016/j.jsbmb.2019.105388.

–Grinman DY, Careaga VP, Wellberg EA, Dansey MV, Kordon EC, Anderson SM, Maier MS, Burton G, MacLean PS, Rudolph MC, Pecci A. Liver X Receptor α Activation Enhances Cholesterol Secretion in Lactating Mammary Epithelium. Am J Physiol Endocrino lMetab. 2019 Apr 9. doi: 10.1152/ajpendo.00548.2018.

-Leonardi DB,  Anselmino N, Brandani JN, Jaworski FM, Páez AV, Mazaira G, Meiss RP, Nuñez M, Nemirovsky SI, Giudice J, Galigniana MD, Pecci A, Gueron G, Vazquez ES, Cotignola J. Heme oxygenase 1 impairsglucocorticoid receptor activity in prostate. Int J Mol Sci. 2019 Feb 26;20(5). doi: 10.3390/ijms20051006.

–Alvarez LD, Pecci A, Estrin DA. In Search of GABA_A Receptor´s Neurosteroid Binding Sites.J Med Chem. 2018 doi: 10.1021/acs.jmedchem.8b01400.

–Alvarez LD, PecciA. Structure and dynamics of neurosteroid binding to the α₁β₂γ₂ GABA_A receptor.J Steroid BiochemMol Biol. 2018 Apr 26. pii: S0960-0760(18)30142-0. doi: 10.1016/j.jsbmb.2018.04.012. 

–Martínez MD, Ghini AA, Dansey MV, Veleiro AS, Pecci A, Alvarez LD, Burton G. Synthesis and activity evaluation of a series of cholanamides as modulators of the liver X receptors.Bioorg Med Chem. 2018 Mar 1;26(5):1092-1101. doi: 10.1016/j.bmc.2018.01.025.

–Stortz M, Angiolini J, Mocksos E, Wolosiuk A, Pecci A and Levi V. Mapping the dynamical organization of the cell nucleus through fluorescence correlation spectroscopy. Methods 2017 doi: 10.1016/j.ymeth.2017.12.008.

–Alvarez LD, Presman DM and Pecci A. Molecular dynamics simulations of the glucocorticoid receptor DNA-binding domain suggest a role of the lever-arm mobility in transcriptional output. PlosOne 2017.12(12):e0189588. DOI: 10.1371/journal.pone.0189588.

–Stortz M, Presman DM, Bruno L, Annibale P, Dansey MV, Burton G, Gratton E, Pecci* A and  Levi* V (*autorascorrespondientes) Mapping the Dynamics of the Glucocorticoid Receptor within the Nuclear Landscape. Scientific Reports, 2017. 7(1):6219-6231 DOI:  10.1038/s41598-017-06676-0

–Rodriguez CR; Alvarez LD; Dansey MV; Paolo LS; Veleiro AS; Pecci A and Burton G. Fluorinated oxysterol analogues: synthesis, molecular modelling and LXRß activity. J of Steroid Biochemistry and Mol Biology. 2017 165(Pt B):268-276. DOI: 10.1016/j.jsbmb.2016.07.001

-Astort F; Repetto EM; Rocha-Viegas L; Mercau ME; Sanchez Puch S; Finkielstein CV; Pecci A and Cymeryng CB. Role of CREB on Heme Oxygenase-1 Induction in Adrenal Cells.Involvement of the PI3K Pathway.J of Molecular Endocrinology. 2016 Aug;57(2):113-24. DOI: 10.1530/JME-16-0005.

–del Fueyo, MC, Dansey, MV, Paolo, LS, Pecci, A, Veleiro, AS and Burton, G. C(16)-C(22) Oxygen-bridged analogues of ceDAF-12 and LXR ligands: Synthesis and biological activity. Steroids.2016 112:109-14. DOI: 10.1016/j.steroids.2016.05.009

–Pecci A, Alvarez LD, Presman DM, Burton G. 21-hydroxy-6,19-epoxyprogesterone: a Promising Therapeutic Agent and a Molecular Tool for Deciphering Glucocorticoid Action. Mini Rev Med Chem. 2016 Jan 17. DOI: 10.2174/1389557517666171002155430

-Grinman DY, Romorini L, Presman DM, Rocha-Viegas L, Coso OA, Davio C and Pecci A. Role of 3′-5′-cyclic Adenosine Monophosphate on the Epidermal Growth Factor Dependent Survival in Mammary Epithelial Cells. Molecular and Cellular Endocrinology. 2016 5;419:259-67. DOI: 10.1016/j.mce.2015.10.026.

-Alvarez LD, Dansey MV, Grinman DG; Navalesi D; Samaja GA, del Fueyo MC; Bastiaensen N; Houtman R; Estrín DA; Veleiro AS; Pecci A* and Burton G* (*autores correspondientes). Destabilization of the torsioned conformation of a ligand side chain inverts the LXRß activity. BBA – Molecular and Cell Biology of Lipids. 2015 1851(12):1577-86. DOI: 10.1016/j.bbalip.2015.09.007

-Chiappe VB, Gómez MV, Rodríguez C, Fresolone M, Pecci A, Romanelli HJ. Subgingivally Applied Minocycline Microgranules in Subjects with Chronic Periodontitis.A Randomized Clinical and Microbiological Trial.Acta Odontol. Latinoam. 2015 Vol. 28 Nº 2:122-131. DOI: 10.1590/S1852-48342015000200005

-Nemirovsky SI, Córdoba M, Zaiat JJ, Completa SP, Vega PA, González-Morón D, Medina NM, Fabbro M, Romero S, Brun B, Revale S, Ogara MF, Pecci A, Marti M, Vazquez M, Turjanski A, Kauffman MA. Whole Genome Sequencing Reveals a De Novo SHANK3 Mutation in Familial Autism Spectrum Disorder. PLoS One. 2015 10(2):e0116358. DOI: 10.1371/journal.pone.0116358

-Dansey MV, Alvarez LD, Samaja G, Escudero DS, Veleiro AS, Pecci A, Castro OA, Burton G. Synthetic DAF-12 modulators with potential use in controlling nematodes life cycle. Biochemical J. 2015. 465(1):175-184. DOI: 0.1042/BJ20140833.